Whether it is sciatica, diabetes or cancer treatment, various nutritionals and herbs have been shown to reduce both the pain,  and damage that causes nerve pain.

Unfortunately most prescription medications are only mildly beneficial bu usually have problematic and worsening side effects (constipation, dry mouth, urinary retention, memory loss, confusion, depression nd addiction).

Thankfully research is highlighting the benefit of various nutritionals and herbs in improving pain relief and reducing the adverse effects of these prescribed medications

In diabetic neuropathy, both acetyl-L-carnitine and Methyl B12 were shown to reduce both pain and disability over a 24 week period.
In another diabetic neuropathy trial, patients with moderate to severe peripheral diabetic neuropathy were given a combination of Vitamins B1 & B12, alongside prescribed Gabapentin and compared to the effects of high dose pregabalin (Lyrica) group.
Both groups showed the same reduction in pain, but with much less side effects in the B1, B12 group. The B1, B12 group required much less gabapentin (at half the dose of gabapentin when used alone) and had less incidence of vertigo and dizziness.
Another study (albeit in rats) showed the benefit of curcumin (turmeric) in relieving nerve pain in diabetics.
Alpha Lipoic acid, known for many years to improve blood sugar control in diabetics, also reduces the pain of diabetic neuropathy. Alpha Lipoic acid also improves blood sugar regulation and can improve a fatty liver  ( Fatty Liver Disease)
The ridiculously long named palmitoylethanolamide, or PEA for short, is a less well known, but well researched solution for nerve pain. It has been shown, both by itself to significantly reduce nerve AND joint pain AND inflammation and also reduce the need for other commonly prescribed nerve pain medications (oxycodone, topiramate, tapentadol) . It acts as both a pain-killer and anti-inflammatory. Partly by reducing the breakdown of your own endocannabinoids, it increases your own supply of these endocannabinoids. Yes, these are the class  of compounds that cannabis has been shown to produce beneficial effects. But fortunately PEA is effective without the adverse psychoactive effects that is produced from other compounds in cannabis.
PEA has also been shown to also relieve depression and improve other neurodegenerative conditions (Parkinsons, Alzheimers)
Unknown to many , there are indeed options available to gain improved pain relief, quality of life and even reduce your prescription medication needs, all without the adverse effects commonly experienced by takers of prescription medications
Journal of diabetes investigation.Effects of acetyl-L-carnitine and
methylcobalamin for diabetic peripheral
neuropathy: A multicenter, randomized,
double-blind, controlled trial
Sheyu Li1†, Xiang Chen2†, Qianrui Li1†, Juan Du1†, Zhimin Liu3, Yongde Peng4, Mian Xu5, Qifu Li6, Minxiang Lei7,
Changjiang Wang8, Shaoxiong Zheng9, Xiaojuan Zhang2, Hongling Yu1, Jinyu Shi1, Shibing Tao1, Ping Feng10,
Haoming Tian1*
1Department of Endocrinology
Journal of Diabetes Research
Volume 2016, Article ID 4078695, 8 pages
Clinical Trial Assessing the Efficacy of Gabapentin Plus B
Complex (B1/B12) versus Pregabalin for Treating Painful
Diabetic Neuropathy
AlbertoMimenza Alvarado and Sara Aguilar Navarro
Neurosci Lett. 2015 Sep 25;605:59-64. doi: 10.1016/j.neulet.2015.08.011. Epub 2015 Aug 14.
Effects of curcumin on TTX-R sodium currents of dorsal root ganglion neurons in type 2 diabetic rats with diabetic neuropathic pain.
Meng B1, Shen LL1, Shi XT1, Gong YS2, Fan XF2, Li J1, Cao H3.
Med Oncol. 2017 Mar;34(3):46. doi: 10.1007/s12032-017-0907-4. Epub 2017 Feb 15.
Use of an alpha lipoic, methylsulfonylmethane and bromelain
dietary supplement (Opera®) for chemotherapy-induced
peripheral neuropathy management, a prospective study.
Desideri I , Francolini G , Becherini C , Terziani F , Delli Paoli C , Olmetto E , Loi M , Perna M ,
Meattini I , Scotti V , Greto D , Bonomo P , Sulprizio S , Livi L .
The Effects of a-Lipoic Acid on Liver Oxidative Stress and Free Fatty Acid
Composition in Methionine–Choline Deficient Diet-Induced NAFLD
Milena N. Stankovic´,1 Dusˇan Mladenovic´,1 Milica Ninkovic´,2 Ivana Ðuricic´,3 SlaCana S ˇ obajic´,3
Bojan Jorgacevic´,1 Silvio de Luka,1 Rada Jesic Vukicevic,4 and Tatjana S. Radosavljevic´1
1Institute of Pathophysiology ‘‘Ljubodrag Buba Mihailovic´,’’ Faculty of Medicine; 3Department for Bromatology,
Faculty of Pharmacy; University of Belgrade, Belgrade, Serbia.
2Institute of Medical Research, Medical Military Academy, Belgrade, Serbia.
4Institute of Digestive Diseases, Clinical Center of Serbia, Belgrade, Serbia.

J Diabetes Complications. 2016 Mar;30(2):350-6. doi: 10.1016/j.jdiacomp.2015.10.018. Epub 2015 Nov 10.
Predictors of improvement and progression of diabetic polyneuropathy following treatment with α-lipoic acid for 4years in the NATHAN 1 trial.

Neurosciences (Riyadh). 2013 Apr;18(2):133-7.
Protective effect of coenzyme Q10 in paclitaxel-induced peripheral neuropathy in rats.
Celebi N1, Cil H, Cil O, Canbay O, Onur R, Aypar U.
The beneficial use of ultramicronized palmitoylethanolamide as add-on therapy to Tapentadol in the treatment of low back  pain: a pilot study comparing prospective  and retrospective observational arms
Maria Beatrice Passavanti, Marco Fiore , Pasquale Sansone, Caterina Aurilii, Vincenzo Pota, Manlio Barbarisi, Daniela Fierro and Maria Caterina Pace

J Pain Res. 2015 Oct 23;8:729-34. doi: 10.2147/JPR.S93106. eCollection 2015.
Palmitoylethanolamide, a neutraceutical, in nerve compression syndromes: efficacy and safety in sciatic pain and carpal tunnel syndrome.
Palmitoylethanolamide as adjunctive therapy in major depressive disorder: A double-blind, randomized and placebo-controlled trial.
Mol Neurobiol. 2018 Mar 19. doi: 10.1007/s12035-018-0959-2. [Epub ahead of print]
N-palmitoylethanolamide Prevents Parkinsonian Phenotypes in Aged Mice.